Limit of
Detection (LOD):
The lowest concentration of an analyze in a sample
that can be detected but not necessarily quantified under the stated
experimental condition.
The limit of detection will be evaluated based on
the standard deviation of the response and slope.
The detection
limit may express as:
3.3 x δ
DL = ------------
S
where
S = the slope of
the calibration curve
δ = standard error
of the linear regression
The calibration curve should be studied using
samples containing an analyte in the range of DL. The standard error of the linear
regression (STEYX) is used as standard deviation and it can be calculated by
Microsoft Excel.
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